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Peripheral memory and naive T cells in non-small cell lung cancer patients with lung metastases undergoing stereotactic body radiotherapy: predictors of early tumor response.

ABSTRACT:

Background

Further analysis of phase I trial of the KEYNOTE-001 has shown that previous radiotherapy improves the outcomes of patients with advanced non-small cell lung cancer (NSCLC) who received pembrolizumab treatment, possibly explained by the radiation-induced specific anti-cancer immunity with a memory effect. In this study, we aimed to investigate the peripheral memory and naïve T cells as predictors of early response in lung metastases post-stereotactic body radiotherapy (SBRT).

Methods

Sixty-six lung metastases patients with NSCLC who received SBRT were enrolled in this study. Analyses of peripheral memory CD4+ T, memory CD8+ T, naive CD4+ T, and naive CD8+ T in NSCLC patients were performed by flow cytometry. Evaluations of the link between immune cells and early radiation response a month after SBRT were carried out via logistic regression analyses.

Results

Higher levels of memory CD4+ T, memory CD8+ T, and lower levels of naïve CD4+ T, CD4+ naïve/memory ratio, and CD8+ naïve/memory ratio were shown in responders compared with non-responders (all P?P?=?0.003; OR: 0.17, 95% CI 0.05-0.66, P?=?0.010), memory CD8+ T (OR: 0.11, 95% CI 0.01-0.87, P?=?0.037; OR: 0.11, 95% CI 0.01-0.97, P?=?0.047), naïve CD4+ T (OR: 16.25, 95% CI 3.17-83.13, P?=?0.001; OR: 12.67, 95% CI 2.26-71.18, P?=?0.004) and CD4+ naïve/memory ratio (OR: 11.27, 95% CI 2.67-47.58, P?=?0.001; OR: 8.50, 95% CI 1.90-38.14, P?=?0.005) were independent predictors for tumor response to SBRT in the lung metastases of NSCLC patients.

Conclusions

The tumor response of lung metastases a month after SBRT independently correlated with peripheral memory CD4+ T, memory CD8+ T, naïve CD4+ T, and CD4+ naïve/memory ratio. These findings could be helpful in incorporating additional treatments to improve clinical outcomes in the case of poor responders.

SUBMITTER: Liu C

PROVIDER: S-EPMC6505218 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Peripheral memory and naïve T cells in non-small cell lung cancer patients with lung metastases undergoing stereotactic body radiotherapy: predictors of early tumor response.

Liu Chao C Hu Qinyong Q Xu Bin B Hu Xiaoyu X Su Huichao H Li Qian Q Zhang Xiaoling X Yue Jinbo J Yu Jinming J

Cancer cell international 20190507

<h4>Background</h4>Further analysis of phase I trial of the KEYNOTE-001 has shown that previous radiotherapy improves the outcomes of patients with advanced non-small cell lung cancer (NSCLC) who received pembrolizumab treatment, possibly explained by the radiation-induced specific anti-cancer immunity with a memory effect. In this study, we aimed to investigate the peripheral memory and naïve T cells as predictors of early response in lung metastases post-stereotactic body radiotherapy (SBRT).< ...[more]

PMID: 31080362

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