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Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

ABSTRACT: We describe the pathologic, histochemical, and immunohistochemical findings associated with pulmonary and encephalitic cryptococcosis in a 3-y-old, mixed-breed, nanny goat from central-west Brazil. The goat had progressive neurologic signs over 30 d; cryptococcosis was diagnosed antemortem by cytologic evaluation of cerebrospinal fluid. Treatment was initiated, but the animal died spontaneously shortly thereafter. Grossly, there was a large space-occupying gelatinous mass (cryptococcoma) in the left lung and smaller masses in the cerebral temporal and frontal cortex, thalamus, hippocampus, basal nuclei, and mesencephalon with consequent internal hydrocephalus. Histologic evaluation revealed marked granulomatous cryptococcal pneumonia and meningoencephalitis. Intralesional narrow-necked budding cryptococcal yeasts were identified on special stains (Mayer mucicarmine and Grocott methenamine silver) in sections of lung and brain. Immunohistochemistry utilizing a panel of monoclonal antibodies that selectively label capsules of Cryptococcus spp. was consistent with C. neoformans var. grubii.

SUBMITTER: Headley SA

PROVIDER: S-EPMC6505750 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

Headley Selwyn A SA Pimentel Luciano A LA Michelazzo Mariana Z MZ Toma Hugo S HS Pretto-Giordano Lucienne G LG Marcasso Rogério A RA Amude Alexandre M AM Oliveira Thalita E TE Santos Marcelo D MD Krockenberger Mark M

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20181212 1

We describe the pathologic, histochemical, and immunohistochemical findings associated with pulmonary and encephalitic cryptococcosis in a 3-y-old, mixed-breed, nanny goat from central-west Brazil. The goat had progressive neurologic signs over 30 d; cryptococcosis was diagnosed antemortem by cytologic evaluation of cerebrospinal fluid. Treatment was initiated, but the animal died spontaneously shortly thereafter. Grossly, there was a large space-occupying gelatinous mass (cryptococcoma) in the ...[more]

PMID: 30541419

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Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

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Pathologic, histochemical, and immunohistochemical findings in pulmonary and encephalitic cryptococcosis in a goat.

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