Ontology highlight
ABSTRACT:
SUBMITTER: Talreja J
PROVIDER: S-EPMC6506207 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Talreja Jaya J Talwar Harvinder H Bauerfeld Christian C Grossman Lawrence I LI Zhang Kezhong K Tranchida Paul P Samavati Lobelia L
eLife 20190501
Sarcoidosis is a complex systemic granulomatous disease of unknown etiology characterized by the presence of activated macrophages and Th1/Th17 effector cells. Data mining of our RNA-Seq analysis of CD14<sup>+</sup>monocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoidosis. Further investigation revealed that sarcoidosis macrophages and monocytes exhibit higher protein levels for HIF-α isoforms, HIF-1β, and their transcriptional co-activator p300 as well ...[more]