Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy.
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ABSTRACT:
SUBMITTER: Minkoff BB
PROVIDER: S-EPMC6506356 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Covalent Modification of Amino Acids and Peptides Induced by Ionizing Radiation from an Electron Beam Linear Accelerator Used in Radiotherapy.
Minkoff Benjamin B BB Bruckbauer Steven T ST Sabat Grzegorz G Cox Michael M MM Sussman Michael R MR
Radiation research 20190308 5
To identify modifications to amino acids that are directly induced by ionizing radiation, free amino acids and 3-residue peptides were irradiated using a linear accelerator (Linac) radiotherapy device. Mass spectrometry was performed to detail the relative sensitivity to radiation as well as identify covalent, radiation-dependent adducts. The order of reactivity of the 20 common amino acids was generally in agreement with published literature except for His (most reactive of the 20) and Cys (les ...[more]
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