Ontology highlight
ABSTRACT:
SUBMITTER: McNaughton AL
PROVIDER: S-EPMC6506499 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
McNaughton Anna L AL Roberts Hannah E HE Bonsall David D de Cesare Mariateresa M Mokaya Jolynne J Lumley Sheila F SF Golubchik Tanya T Piazza Paolo P Martin Jacqueline B JB de Lara Catherine C Brown Anthony A Ansari M Azim MA Bowden Rory R Barnes Eleanor E Matthews Philippa C PC
Scientific reports 20190508 1
Advancing interventions to tackle the huge global burden of hepatitis B virus (HBV) infection depends on improved insights into virus epidemiology, transmission, within-host diversity, drug resistance and pathogenesis, all of which can be advanced through the large-scale generation of full-length virus genome data. Here we describe advances to a protocol that exploits the circular HBV genome structure, using isothermal rolling-circle amplification to enrich HBV DNA, generating concatemeric ampli ...[more]