Ontology highlight
ABSTRACT:
SUBMITTER: Chen R
PROVIDER: S-EPMC6506611 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Rui R Xia Wenjia W Wang Siwei S Xu Youtao Y Ma Zhifei Z Xu Weizhang W Zhang Erbao E Wang Jie J Fang Tian T Zhang Quan'an Q Dong Gaochao G Cho William Chi-Shing WC Ma Patrick C PC Brandi Giovanni G Tavolari Simona S Ujhazy Peter P Metro Giulio G Popper Helmut H HH Yin Rong R Qiu Mantang M Xu Lin L
Molecular therapy. Nucleic acids 20190413
Emerging evidence demonstrates that long non-coding RNAs (lncRNAs) are deeply involved in the development of various cancers. This study identified that SBF2-AS1, an early-stage-specific lncRNA, is critical for the tumorigenesis of lung adenocarcinoma (LUAD). We first analyzed LUAD transcriptome data from The Cancer Genome Atlas and the GEO database by weighted gene co-expression network analysis (WGCNA). Five early LUAD-specific lncRNAs were filtered out, and only SBF2-AS1 was upregulated in LU ...[more]