Ontology highlight
ABSTRACT:
SUBMITTER: Blech M
PROVIDER: S-EPMC6506711 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Blech Michaela M Hörer Stefan S Kuhn Alexander B AB Kube Sebastian S Göddeke Hendrik H Kiefer Hans H Zang Yuguo Y Alber Yannic Y Kast Stefan M SM Westermann Martin M Tully Mark D MD Schäfer Lars V LV Garidel Patrick P
Biophysical journal 20190405 9
We report the x-ray crystal structure of intact, full-length human immunoglobulin (IgG4) at 1.8 Å resolution. The data for IgG4 (S228P), an antibody targeting the natriuretic peptide receptor A, show a previously unrecognized type of Fab-Fc orientation with a distorted λ-shape in which one Fab-arm is oriented toward the Fc portion. Detailed structural analysis by x-ray crystallography and molecular simulations suggest that this is one of several conformations coexisting in a dynamic equilibrium ...[more]