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Incidence and radiological pattern of eosinophilic granuloma: a retrospective study in a Chinese tertiary hospital.


ABSTRACT:

Background

The incidence and radiological patterns of eosinophilic granuloma (EG) in China is not clear. We described the incidence, presentation, and imaging characteristics of Chinese EG patients in a tertiary hospital.

Methods

A retrospective chart review was performed from January 2004 to October 2017 at a single tertiary general hospital. Seventy-six patients were pathologically identified as EG. Besides, 60 patients with preoperative imaging diagnosis of "EG" were analyzed to reveal the radiological patterns and their diagnostic power.

Results

Fifty-three male and 23 female EG patients with a mean age of 18.1 ± 16.7?years (range 1-58?years) were retrospectively included. Significant differences were observed in gender (male to female = 2.3:1) and age (the highest incidence at the age of 0~5?years) for EG. EG predominantly involved the skeletal system: flat bones (31.43%) > irregular bones (24.76%) > long bones (22.86%) > other organs (20.95%). No obvious relationships between season, biochemical markers, and EG incidence were observed. The common presenting symptoms were pain followed with local mass, and most patients underwent surgical resection. Among 60 imagingly diagnosed "EG" patients from April 2009 to October 2017, only 22 were with histological confirmation. The correct diagnosis rates were 37.1% (13 out of 35), 16.7% (5 out of 30), and 22.2% (8 out of 36) for plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI), respectively.

Conclusions

Chinese EG has a varied presentation, age distribution, and gender difference. EG diagnosis is still based on biopsy or histopathology instead of imaging techniques.

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC6507022 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Incidence and radiological pattern of eosinophilic granuloma: a retrospective study in a Chinese tertiary hospital.

Zhao Sha-Sha SS   Yan Lin-Feng LF   Feng Xiu-Long XL   Du Pang P   Chen Bao-Ying BY   Dong Wen-Ting WT   Gao Yi Y   He Jie-Bing JB   Cui Guang-Bin GB   Wang Wen W  

Journal of orthopaedic surgery and research 20190509 1


<h4>Background</h4>The incidence and radiological patterns of eosinophilic granuloma (EG) in China is not clear. We described the incidence, presentation, and imaging characteristics of Chinese EG patients in a tertiary hospital.<h4>Methods</h4>A retrospective chart review was performed from January 2004 to October 2017 at a single tertiary general hospital. Seventy-six patients were pathologically identified as EG. Besides, 60 patients with preoperative imaging diagnosis of "EG" were analyzed t  ...[more]

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