Ontology highlight
ABSTRACT:
SUBMITTER: Honrubia-Gomez P
PROVIDER: S-EPMC6508205 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Oncotarget 20190426 31
Relapse after chemotherapy treatment depends on the cancer initiating cells (CICs). PEDF (Pigmented Epithelium Derived Factor) is an anti-angiogenic, neurotrophic and self-renewal regulator molecule, also involved in CICs biology. Acute and chronic exposition of colon cancer cell lines to CT/CTE PEDF-derived peptides decreased drug-resistance to conventional colorectal cancer treatments, such as oxaliplatin or irinotecan. We confirmed a reduction in the irinotecan and oxaliplatin IC50 doses for ...[more]