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Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.


ABSTRACT: Background:Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to microbial products are key drivers of this inflammation. Serum-derived bovine immunoglobulin/protein isolate (SBI) supports gut healing in other conditions such as inflammatory bowel disease. Methods:In this randomized, double-blind study, participants receiving suppressive antiretroviral therapy (ART) with chronic diarrhea received placebo or SBI at 2.5 g BID or 5 g BID for 4 weeks, followed by a 20-week placebo-free extension phase with SBI at either 2.5 or 5 g BID. Intestinal fatty acid binding protein (I-FABP), zonulin, flagellin, lipopolysaccharide (LPS) and LPS-binding protein, and inflammatory markers were measured by ELISA or multiplex assays. Non-parametric tests were used for analysis. Results:One hundred three participants completed the study. By week 24 SBI significantly decreased circulating levels of I-FABP (-0.35 ng/?L, P=0.002) and zonulin (-4.90 ng/?L, P=0.003), suggesting improvement in gut damage, and interleukin-6 (IL-6) (-0.40 pg/?L, P=0.002), reflecting improvement in systemic inflammation. In participants with the lowest quartile of CD4+ T-cell counts at baseline (189-418 cells/?L), CD4+ T-cell counts increased significantly (26 cells/?L; P=0.002). Conclusions:Oral SBI may decrease inflammation and warrants further exploration as a potential strategy to improve gut integrity and decrease systemic inflammation among persons receiving prolonged suppressive ART.

SUBMITTER: Utay NS 

PROVIDER: S-EPMC6508431 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Serum Bovine Immunoglobulins Improve Inflammation and Gut Barrier Function in Persons with HIV and Enteropathy on Suppressive ART.

Utay Netanya S NS   Somasunderam Anoma A   Hinkle John E JE   Petschow Bryon W BW   Detzel Christopher J CJ   Somsouk Ma M   Fichtenbaum Carl J CJ   Weaver Eric M EM   Shaw Audrey L AL   Asmuth David M DM  

Pathogens & immunity 20190503 1


<h4>Background</h4>Systemic inflammation persists in chronic HIV infection and is associated with increased rates of non-AIDS events such as cardiovascular and liver disease. Increased gut permeability and systemic exposure to microbial products are key drivers of this inflammation. Serum-derived bovine immunoglobulin/protein isolate (SBI) supports gut healing in other conditions such as inflammatory bowel disease.<h4>Methods</h4>In this randomized, double-blind study, participants receiving sup  ...[more]

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