Ontology highlight
ABSTRACT:
SUBMITTER: Templeton N
PROVIDER: S-EPMC6508663 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Templeton Nikki N Kivell Bronwyn B McCaughey-Chapman Amy A Connor Bronwen B La Flamme Anne Camille AC
PloS one 20190509 5
The atypical antipsychotic agent, clozapine, is used to treat a variety of neurological disorders including schizophrenia and Parkinson's disease and readily crosses the blood brain barrier to interact with a wide range of neuroreceptors including those for dopamine and serotonin. Recent work has shown that clozapine can reduce neuroinflammation in experimental autoimmune encephalomyelitis, a neuroinflammatory model of multiple sclerosis (MS) and mediates its effects in the central nervous syste ...[more]