Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial.

ABSTRACT:

Background

Akkermansia muciniphila (AM) is a gram-negative, mucin-degrading bacteria inhabiting the gastrointestinal tract associated with host phenotypes and disease states.

Objective

Explore characteristics of overweight and obese female early-stage (0 to II) breast cancer patients with low AM relative abundance (LAM) vs high (HAM) enrolled in a presurgical weight-loss trial.

Design

Secondary analysis of pooled participants in a randomized controlled trial (NCT02224807).

Participants/setting

During the period from 2014 to 2017, 32 female patients with breast cancer were randomized to weight-loss or attention-control arms from time of diagnosis-to-lumpectomy (mean=30±9 days).

Intervention

All were instructed to correct nutrient deficiencies via food sou

SUBMITTER: Fruge AD 

PROVIDER: S-EPMC6509025 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature