Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC6509079 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cheng Ying Y Yu Xiaochen X Zhang Jie J Chang Yunpeng Y Xue Mei M Li Xiaoyu X Lu Yunhong Y Li Ting T Meng Ziyu Z Su Long L Sun Bei B Chen Liming L
Diabetologia 20190305 6
<h4>Aims/hypothesis</h4>Many studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its effects on diabetic retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic kallikrein and studied potential mechanisms of action.<h4>Methods</h4>We used KK Cg-A<sup>y</sup>/J (KKAy) mice (a mouse model of spontaneous type 2 diabetes) and mice with high-fat diet/strep ...[more]