Ontology highlight
ABSTRACT:
SUBMITTER: Kamermans A
PROVIDER: S-EPMC6509157 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kamermans Alwin A Rijnsburger Merel M Chakraborty Ananya A van der Pol Susanne S de Vries Helga E HE van Horssen Jack J
Frontiers in immunology 20190503
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques. Sufficient clearance of myelin and cellular debris is one of the requirements for proper tissue repair and remyelination. The mechanisms underlying the clearance of such debris by phagocytes are not fully understood, but recent findings suggest a prominent role for lipoprotein-lipase (LPL) in this process. Here, we demonstrate that angiopoiet ...[more]