Ontology highlight
ABSTRACT:
SUBMITTER: Carvalho D
PROVIDER: S-EPMC6509210 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190509
Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in <i>ACVR1</i>, encoding the serine/threonine kinase ALK2. Despite being an amenable drug target, little has been done to-date to systematically evaluate the role of <i>ACVR1</i> in DIPG, nor to screen currently available inhibitors in patient-derived tumour models. Here we show the dependence of DIPG cells on the mutant receptor, and the preclinical efficacy o ...[more]