Dataset Information

Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

ABSTRACT:

Background

Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1?s (dFEV₁). This study investigated whether indices of airway inflammation are predictors of dFEV₁ in a general population-based sample.

Methods

The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70?years old. At baseline, the participants completed a self-administered respiratory questionnaire and underwent a clinical examination that included spirometry, venous blood sampling, and induced sputum examination. From 2015 to 2016, 62 (52%) participants agreed to a follow-up examination that did not include induced sputum examination. Those with a FEV₁/forced vital capacity (FVC) ratio?1 were then analysed.

Results

The mean dFEV₁ was 32.9?ml/year (standard deviation 26.3). We found no associations between dFEV₁ and the baseline indices of sputum inflammation. Seven participants had irreversible airflow limitation at follow-up. They had lower FEV1 and gas diffusion at baseline compared with the remaining subjects. Moreover, two of these individuals had a positive reversibility test and sputum eosinophilia at baseline.

Conclusions

In this cohort of presumably healthy subjects, we found no associations between sputum inflammatory cells or mediators and dFEV₁ during 10?years of follow-up.

SUBMITTER: Kononova N

PROVIDER: S-EPMC6509765 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

Kononova Natalia N Sikkeland Liv Ingunn Bjoner LIB Mahmood Faiza F Vistnes Maria M Kongerud Johny J Einvik Gunnar G Søyseth Vidar V

BMC pulmonary medicine 20190509 1

<h4>Background</h4>Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV<sub>1</sub>). This study investigated whether indices of airway inflammation are predictors of dFEV<sub>1</sub> in a general population-based sample.<h4>Methods</h4>The study, conducted from 2003 to 2005, included 120 healthy Norwegian subjects aged 40 to 70 years old. At baseline, the participants completed a self-administered ...[more]

PMID: 31072364

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Project description:Rationale: The American Thoracic Society (ATS)/European Respiratory Society defines a positive bronchodilator response (BDR) by a composite of BDR in either forced expiratory volume in 1 second (FEV1) and/or forced vital capacity (FVC) greater than or equal to 12% and 200 ml (ATS-BDR). We hypothesized that ATS-BDR components would be differentially associated with important chronic obstructive pulmonary disease (COPD) outcomes. Objectives: To examine whether ATS-BDR components are differentially associated with clinical, functional, and radiographic features in COPD. Methods: We included subjects with COPD enrolled in the COPDGene study. In the main analysis, we excluded subjects with self-reported asthma. We categorized BDR into the following: 1) No-BDR, no BDR in either FEV1 or FVC; 2) FEV1-BDR, BDR in FEV1 but no BDR in FVC; 3) FVC-BDR, BDR in FVC but no BDR in FEV1; and 4) Combined-BDR, BDR in both FEV1 and FVC. We constructed multivariable logistic, linear, zero-inflated negative binomial, and Cox hazards models to examine the association of BDR categories with symptoms, computed tomography findings, change in FEV1 over time, respiratory exacerbations, and mortality. We also created models using the ATS BDR definition (ATS-BDR) as the main independent variable. Results: Of 3,340 COPD subjects included in the analysis, 1,083 (32.43%) had ATS-BDR, 182 (5.45%) had FEV1-BDR, 522 (15.63%) had FVC-BDR, and 379 (11.34%) had Combined-BDR. All BDR categories were associated with FEV1 decline compared with No-BDR. Compared with No-BDR, both ATS-BDR and Combined-BDR were associated with higher functional residual capacity %predicted, greater internal perimeter of 10 mm, and greater 6-minute-walk distance. In contrast to ATS-BDR, Combined-BDR was independently associated with less emphysema (adjusted beta regression coefficient, -1.67; 95% confidence interval [CI], -2.68 to -0.65; P = 0.001), more frequent respiratory exacerbations (incidence rate ratio, 1.25; 95% CI, 1.03-1.50; P = 0.02) and severe exacerbations (incidence rate ratio, 1.34; 95% CI, 1.05-1.71; P = 0.02), and lower mortality (adjusted hazards ratio, 0.76; 95% CI, 0.58-0.99; P = 0.046). Sensitivity analysis that included subjects with self-reported history of asthma showed similar findings. Conclusions: BDR in both FEV1 and FVC indicates a COPD phenotype with asthma-like characteristics, and provides clinically more meaningful information than current definitions of BDR.

Dataset Information

Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

Background

Methods

Results

Conclusions

Publications

Annual decline in forced expiratory volume and airway inflammatory cells and mediators in a general population-based sample.

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