Ontology highlight
ABSTRACT:
SUBMITTER: Semple KM
PROVIDER: S-EPMC6510375 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Semple Kenrick M KM Gonzaléz Carlos M CM Zarr Melissa M Austin José R JR Patel Vikram V Howard Kristina E KE
Clinical and translational science 20190227 3
CD20 monoclonal antibodies are well-established therapeutics for the treatment of B-cell malignancies. Several mechanisms of target cell killing occur from anti-CD20 therapy, including complement-dependent cytotoxicity (CDC) cell lysis and antibody-dependent cell-mediated cytotoxicity. Human Fc receptors (FcRs) are required to mediate these functions and are either not present or not cross-reactive in mice and most animal species. In contrast, some nonhuman primates have cross-reactive FcR; howe ...[more]