Ontology highlight
ABSTRACT:
SUBMITTER: Henderson LM
PROVIDER: S-EPMC6510382 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Henderson Lindsay M LM Robinson Renee F RF Ray Lily L Khan Burhan A BA Li Tianran T Dillard Denise A DA Schilling Brian D BD Mosley Mike M Janssen Patricia L PL Fohner Alison E AE Rettie Allan E AE Thummel Kenneth E KE Thornton Timothy A TA Veenstra David L DL
Clinical and translational science 20190301 3
Alaska Native and American Indian (AN/AI) people have unique pharmacogene variation that may affect warfarin disposition and therapeutic response. We performed targeted genotyping for cytochrome P450 (CYP)2C9, vitamin K epoxide oxidase reductase complex subunit 1 (VKORC1), CYP4F2, CYP4F11, and gamma-glutamyl carboxylase (GGCX) variants in AN/AI people receiving warfarin. The primary outcome was stable warfarin dose, defined as one dose, and associated international normalized ratio within the ta ...[more]