Ontology highlight
ABSTRACT:
SUBMITTER: Khedkar A
PROVIDER: S-EPMC6510383 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Khedkar Anand A Lebovitz Harold H Fleming Alexander A Cherrington Alan A Jose Vinu V Athalye Sandeep N SN Vishweswaramurthy Ashwini A
Clinical and translational science 20190212 3
Oral insulin tregopil (IN-105; a new drug under development) may be coadministered with oral antidiabetic drugs, such as metformin in patients with type 2 diabetes mellitus for optimal glycemic control. IN-105 has sodium caprate excipient, a permeation enhancer, for enhancing absorption in the stomach and increasing bioavailability via an oral route. Sodium caprate may increase bioavailability of metformin by a similar mechanism. Therefore, it was necessary to study the effect of IN-105 on pharm ...[more]