Ontology highlight
ABSTRACT:
SUBMITTER: Kauffman AC
PROVIDER: S-EPMC6510397 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kauffman Amy C AC Piotrowski-Daspit Alexandra S AS Nakazawa Kay H KH Jiang Yuhang Y Datye Amit A Saltzman W Mark WM
Biomacromolecules 20180828 9
Gene therapy promises to treat diseases that arise from genetic abnormalities by correcting the underlying cause of the disease rather than treating the associated symptoms. Successful transfer of nucleic acids into cells requires efficient delivery vehicles that protect the cargo and can penetrate the appropriate cellular barriers before releasing their contents. Many viral vectors and synthetic polycationic vectors for nucleic acid delivery do not translate well from in vitro to in vivo applic ...[more]