Ontology highlight
ABSTRACT:
SUBMITTER: Wageling NB
PROVIDER: S-EPMC6510400 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wageling Nicholas B NB Decato Daniel A DA Berryman Orion B OB
Supramolecular chemistry 20180911 12
The study of hydrogen bonding organocatalysis is rapidly expanding. Much research has been directed at making catalysts more active and selective, with less attention on fundamental design strategies. This study systematically increases steric hindrance at the active site of pH switchable urea organocatalysts. Incorporating strong intramolecular hydrogen bonds from protonated pyridines to oxygen stabilizes the active conformation of these ureas thus reducing the entropic penalty that results fro ...[more]