Dataset Information

Longitudinal fan-beam computed tomography dataset for head-and-neck squamous cell carcinoma patients.

ABSTRACT: PURPOSE:To describe in detail a dataset consisting of longitudinal fan-beam computed tomography (CT) imaging to visualize anatomical changes in head-and-neck squamous cell carcinoma (HNSCC) patients throughout radiotherapy (RT) treatment course. ACQUISITION AND VALIDATION METHODS:This dataset consists of CT images from 31 HNSCC patients who underwent volumetric modulated arc therapy (VMAT). Patients had three CT scans acquired throughout the duration of the radiation treatment course. Pretreatment planning CT scans with a median of 13 days before treatment (range: 2-27), mid-treatment CT at 22 days after start of treatment (range: 13-38), and post-treatment CT 65 days after start of treatment (range: 35-192). Patients received RT treatment to a total dose of 58-70 Gy, using daily 2.0-2.20 Gy, fractions for 30-35 fractions. The fan-beam CT images were acquired using a Siemens 16-slice CT scanner head protocol with 120 kV and current of 400 mAs. A helical scan with 1 rotation per second was used with a slice thickness of 2 mm and table increment of 1.2 mm. In addition to the imaging data, contours of anatomical structures for RT, demographic, and outcome measurements are provided. DATA FORMAT AND USAGE NOTES:The dataset with DICOM files including images, RTSTRUCT files, and RTDOSE files can be found and publicly accessed in the Cancer Imaging Archive (TCIA, http://www.cancerimagingarchive.net/) as collection Head-and-neck squamous cell carcinoma patients with CT taken during pretreatment, mid-treatment, and post-treatment (HNSCC-3DCT-RT). DISCUSSION:This is the first dataset to date in TCIA which provides a collection of multiple CT imaging studies (pretreatment, mid-treatment, and post-treatment) throughout the treatment course. The dataset can serve a wide array of research projects including (but not limited to): quantitative imaging assessment, investigation on anatomical changes with treatment progress, dosimetry of target volumes and/or normal structures due to anatomical changes occurring during treatment, investigation of RT toxicity, and concurrent chemotherapy and RT effects on head-and-neck patients.

SUBMITTER: Bejarano T

PROVIDER: S-EPMC6510641 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Longitudinal fan-beam computed tomography dataset for head-and-neck squamous cell carcinoma patients.

Bejarano Tatiana T De Ornelas-Couto Mariluz M Mihaylov Ivaylo B IB

Medical physics 20190312 5

<h4>Purpose</h4>To describe in detail a dataset consisting of longitudinal fan-beam computed tomography (CT) imaging to visualize anatomical changes in head-and-neck squamous cell carcinoma (HNSCC) patients throughout radiotherapy (RT) treatment course.<h4>Acquisition and validation methods</h4>This dataset consists of CT images from 31 HNSCC patients who underwent volumetric modulated arc therapy (VMAT). Patients had three CT scans acquired throughout the duration of the radiation treatment cou ...[more]

PMID: 30806479

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Project description:To describe in detail a dataset consisting of serial four-dimensional computed tomography (4DCT) and 4D cone beam CT (4DCBCT) images acquired during chemoradiotherapy of 20 locally advanced, nonsmall cell lung cancer patients we have collected at our institution and shared publicly with the research community.As part of an NCI-sponsored research study 82 4DCT and 507 4DCBCT images were acquired in a population of 20 locally advanced nonsmall cell lung cancer patients undergoing radiation therapy. All subjects underwent concurrent radiochemotherapy to a total dose of 59.4-70.2 Gy using daily 1.8 or 2 Gy fractions. Audio-visual biofeedback was used to minimize breathing irregularity during all fractions, including acquisition of all 4DCT and 4DCBCT acquisitions in all subjects. Target, organs at risk, and implanted fiducial markers were delineated by a physician in the 4DCT images. Image coordinate system origins between 4DCT and 4DCBCT were manipulated in such a way that the images can be used to simulate initial patient setup in the treatment position. 4DCT images were acquired on a 16-slice helical CT simulator with 10 breathing phases and 3 mm slice thickness during simulation. In 13 of the 20 subjects, 4DCTs were also acquired on the same scanner weekly during therapy. Every day, 4DCBCT images were acquired on a commercial onboard CBCT scanner. An optically tracked external surrogate was synchronized with CBCT acquisition so that each CBCT projection was time stamped with the surrogate respiratory signal through in-house software and hardware tools. Approximately 2500 projections were acquired over a period of 8-10 minutes in half-fan mode with the half bow-tie filter. Using the external surrogate, the CBCT projections were sorted into 10 breathing phases and reconstructed with an in-house FDK reconstruction algorithm. Errors in respiration sorting, reconstruction, and acquisition were carefully identified and corrected.4DCT and 4DCBCT images are available in DICOM format and structures through DICOM-RT RTSTRUCT format. All data are stored in the Cancer Imaging Archive (TCIA, http://www.cancerimagingarchive.net/) as collection 4D-Lung and are publicly available.Due to high temporal frequency sampling, redundant (4DCT and 4DCBCT) data at similar timepoints, oversampled 4DCBCT, and fiducial markers, this dataset can support studies in image-guided and image-guided adaptive radiotherapy, assessment of 4D voxel trajectory variability, and development and validation of new tools for image registration and motion management.

Dataset Information

Longitudinal fan-beam computed tomography dataset for head-and-neck squamous cell carcinoma patients.

Publications

Longitudinal fan-beam computed tomography dataset for head-and-neck squamous cell carcinoma patients.

Similar Datasets

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