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Intermittently tagged real-time MRI reveals internal tongue motion during speech production.

ABSTRACT: PURPOSE:To demonstrate a tagging method compatible with RT-MRI for the study of speech production. METHODS:Tagging is applied as a brief interruption to a continuous real-time spiral acquisition. Tagging can be initiated manually by the operator, cued to the speech stimulus, or be automatically applied with a fixed frequency. We use a standard 2D 1-3-3-1 binomial SPAtial Modulation of Magnetization (SPAMM) sequence with 1 cm spacing in both in-plane directions. Tag persistence in tongue muscle is simulated and validated in vivo. The ability to capture internal tongue deformations is tested during speech production of American English diphthongs in native speakers. RESULTS:We achieved an imaging window of 650-800 ms at 1.5T, with imaging signal to noise ratio ? 17 and tag contrast to noise ratio ? 5 in human tongue, providing 36 frames/s temporal resolution and 2 mm in-plane spatial resolution with real-time interactive acquisition and view-sharing reconstruction. The proposed method was able to capture tongue motion patterns and their relative timing with adequate spatiotemporal resolution during the production of American English diphthongs and consonants. CONCLUSION:Intermittent tagging during real-time MRI of speech production is able to reveal the internal deformations of the tongue. This capability will allow new investigations of valuable spatiotemporal information on the biomechanics of the lingual subsystems during speech without reliance on binning speech utterance repetition.

SUBMITTER: Chen W

PROVIDER: S-EPMC6510652 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Project description:Dynamic imaging of the vocal tract using real-time MRI has been an active and growing area of research, having demonstrated great potential to become routinely performed in the clinical evaluation of speech and swallowing disorders. Although many technical advances have been made in regards to acquisition and reconstruction methodologies, there is still no consensus in best practice protocols. This study aims to compare Cartesian and non-Cartesian real-time MRI sequences, regarding image quality and temporal resolution trade-off, for dynamic speech imaging. Five subjects were imaged at 1.5T, while performing normal phonation, in order to assess velar motion and velopharyngeal closure. Data was acquired using both Cartesian and non-Cartesian (spiral and radial) real-time sequences at five different spatial-temporal resolution sets, between 10 fps (1.7×1.7×10 mm3) and 25 fps (1.5×1.5×10 mm3). Only standard scanning resources provided by the MRI scanner manufacturer were used to ensure easy applicability to clinical evaluation and reproducibility. Data sets were evaluated by comparing measurements of the velar structure, dynamic contrast-to-noise ratio and image quality visual scoring. Results showed that for all proposed sequences, FLASH spiral acquisitions provided higher contrast-to-noise ratio, up to a 170.34% increase at 20 fps, than equivalent bSSFP Cartesian acquisitions for the same spatial-temporal resolution. At higher frame rates (22 and 25 fps), spiral protocols were optimal and provided higher CNR and visual scoring than equivalent radial protocols. Comparison of dynamic imaging at 10 and 22 fps for radial and spiral acquisitions revealed no significant difference in CNR performance, thus indicating that temporal resolution can be doubled without compromising spatial resolution (1.9×1.9 mm2) or CNR. In summary, this study suggests that the use of FLASH spiral protocols should be preferred over bSSFP Cartesian for the dynamic imaging of velopharyngeal closure, as it allows for an improvement in CNR and overall image quality without compromising spatial-temporal resolution.

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Intermittently tagged real-time MRI reveals internal tongue motion during speech production.

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