Ontology highlight
ABSTRACT:
SUBMITTER: Kondo S
PROVIDER: S-EPMC6510754 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kondo Shunsuke S Takahashi Kazuya K Kinoshita Yuki Y Nagai Jun J Wakatsuki Shuji S Araki Toshiyuki T Araki Toshiyuki T Goshima Yoshio Y Ohshima Toshio T
Scientific reports 20190510 1
Axonal degeneration occurs in various neurological diseases and traumatic nerve injury, and axonal regeneration is restricted by inhibitory factors in the central nervous system. Cyclin-dependent kinase 5 and glycogen synthase kinase 3β (GSK3β) are activated by one of those inhibitors, and collapsin response mediator protein 2 (CRMP2) is phosphorylated by both kinases. We previously developed a CRMP2 knock-in (CRMP2 KI) mouse line, in which CRMP2 phosphorylation at Ser 522 is inhibited. Because ...[more]