Ontology highlight
ABSTRACT:
SUBMITTER: Rigby RE
PROVIDER: S-EPMC6510759 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Rigby Rachel E RE Wise Helen M HM Smith Nikki N Digard Paul P Rehwinkel Jan J
Scientific reports 20190510 1
The sensing of viral nucleic acids by the innate immune system activates a potent antiviral response in the infected cell, a key component of which is the expression of genes encoding type I interferons (IFNs). Many viruses counteract this response by blocking the activation of host nucleic acid sensors. The evolutionarily conserved influenza A virus (IAV) protein PA-X has been implicated in suppressing the host response to infection, including the expression of type I IFNs. Here, we characteris ...[more]