Ontology highlight
ABSTRACT:
SUBMITTER: Muller S
PROVIDER: S-EPMC6510792 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Muller Sandra S Ader Isabelle I Creff Justine J Leménager Hélène H Achard Pauline P Casteilla Louis L Sensebé Luc L Carrière Audrey A Deschaseaux Frédéric F
Scientific reports 20190510 1
Native human subcutaneous adipose tissue (AT) is well organized into unilocular adipocytes interspersed within dense vascularization. This structure is completely lost under standard culture conditions and may impair the comparison with native tissue. Here, we developed a 3-D model of human white AT reminiscent of the cellular architecture found in vivo. Starting with adipose progenitors derived from the stromal-vascular fraction of human subcutaneous white AT, we generated spheroids in which en ...[more]