Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice.

ABSTRACT:

Objective

To assess functional changes in lymphocyte repertoire and subsequent clinical implications during delayed-release dimethyl fumarate (DMF) treatment in patients with multiple sclerosis.

Methods

Using peripheral blood from several clinical trials of DMF, immune cell subsets were quantified using flow cytometry. For some patients, lymphocyte counts were assessed after DMF discontinuation. Incidence of adverse events, including serious and opportunistic infections, was assessed.

Results

In DMF-treated patients, absolute lymphocyte counts (ALCs) demonstrated a pattern of decline followed by stabilization, which also was reflected in the global reduction in numbers of circulating functional lymphocyte subsets. The relative frequencies of circulating memory T- and

SUBMITTER: Mehta D 

PROVIDER: S-EPMC6511089 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature