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Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms.


ABSTRACT: OBJECTIVE:The aim of this study was to test the feasibility of an exercise augmentation to pharmacotherapy in depressed younger and older adults while exploring neural mechanisms. METHODS:A randomized, double-blind, controlled clinical trial was conducted in 15 inactive younger (20-39 years) and older (60-79 years) adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a major depressive episode (https://clinicaltrials.gov/ct2/show/NCT02407704). Participants were randomized to receive a 12-week regimen of venlafaxine XR or venlafaxine XR plus supervised exercise. Cardiorespiratory fitness was assessed using a submaximal Vo2 test, and neuroimaging assessments were conducted using a Siemans MAGNETOM 7-Tesla magnetic resonance scanner at the University of Pittsburgh. RESULTS:Attrition was 38% and 14% for the medication and exercise groups, respectively. Attendance was 91% for the exercise intervention. Exploratory analyses revealed an association between improvement in fitness and increased cortical thickness in the anterior cingulate cortex. CONCLUSION:Exercise augmentation to pharmacotherapy is feasible for depressed younger and older adults and may have neural benefits in a core brain region implicated in depression.

SUBMITTER: Gujral S 

PROVIDER: S-EPMC6511318 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Exercise for Depression: A Feasibility Trial Exploring Neural Mechanisms.

Gujral Swathi S   Aizenstein Howard H   Reynolds Charles F CF   Butters Meryl A MA   Grove George G   Karp Jordan F JF   Erickson Kirk I KI  

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20190117 6


<h4>Objective</h4>The aim of this study was to test the feasibility of an exercise augmentation to pharmacotherapy in depressed younger and older adults while exploring neural mechanisms.<h4>Methods</h4>A randomized, double-blind, controlled clinical trial was conducted in 15 inactive younger (20-39 years) and older (60-79 years) adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria for a major depressive episode (https://clinicaltrials.gov/ct2/show/NCT024  ...[more]

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