Ontology highlight
ABSTRACT:
SUBMITTER: Sinha A
PROVIDER: S-EPMC6511374 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20190301 3
DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic dysregulation on the tumor proteome remains poorly understood. We profiled the genomes, epigenomes, transcriptomes, and proteomes of 76 localized, intermediate-risk prostate cancers. We discovered that the genomic subtypes of prostate cancer converge on five proteomic subtypes, with distinct clinical trajectories. ETS fusions, ...[more]