The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Whitwell JL
PROVIDER: S-EPMC6511453 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.
Whitwell Jennifer L JL Martin Peter P Graff-Radford Jonathan J Machulda Mary M MM Senjem Matthew L ML Schwarz Christopher G CG Weigand Stephen D SD Spychalla Anthony J AJ Drubach Daniel A DA Jack Clifford R CR Lowe Val J VJ Josephs Keith A KA
Alzheimer's & dementia : the journal of the Alzheimer's Association 20190308 5
<h4>Introduction</h4>Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD).<h4>Methods</h4>Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model.<h4>Results</h4>Age was strongly associated with tau ...[more]
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