Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC6511756 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhao Xingyu X Wang Tiejun T Cai Bo B Wang Xiaoning X Feng Wei W Han Yu Y Li Dongsong D Li Shuqiang S Liu Jianguo J
American journal of translational research 20190415 4
Osteoarthritis (OA) is a common multifactorial degenerative articular disease among the aging population. The current investigation aimed to elucidate the function of microRNA-495 (miR-495) in the development of OA. We found that miR-495 was upregulated in the cartilage of OA patients. Transfection of a miR-495 mimic into rat primary chondrocytes, human chondrocytes (HC) and SW1353 chondrosarcoma cells inhibited AKT1 expression, proliferation and scratch wound closure and induced apoptosis. Tran ...[more]