Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC6512328 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Liu Lily L Li Liuzhe L Nanfack Aubin A Mayr Luzia M LM Soni Sonal S Kohutnicki Adam A Agyingi Lucy L Wang Xiao-Hong XH Tuen Michael M Shao Yongzhao Y Totrov Maxim M Zolla-Pazner Susan S Kong Xian-Peng XP Duerr Ralf R Gorny Miroslaw K MK
Virology 20190114
The results of the RV144 vaccine clinical trial showed a correlation between high level of anti-V1V2 antibodies (Abs) and a decreased risk of acquiring HIV-1 infection. This turned the focus of HIV vaccine design to the induction of elevated levels of anti-V2 Abs to increase vaccine efficacy. In plasma samples from HIV-1 infected Cameroonian individuals, we observed broad variations in levels of anti-V2 Abs, and 6 of the 79 plasma samples tested longitudinally displayed substantial deficiency of ...[more]