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Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis.

ABSTRACT: Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions. Distinguishing features of this arylation protocol include its mild reaction conditions, high chemoselectivity, and adaptability to a variety of complex substrates [i.e., pyridinium salts derived from amines and partners derived from (hetero)aryl bromides].

SUBMITTER: Yi J

PROVIDER: S-EPMC6512806 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis.

Yi Jun J Badir Shorouk O SO Kammer Lisa Marie LM Ribagorda María M Molander Gary A GA

Organic letters 20190417 9

Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions. Distinguishing features of this arylation protocol include its mild reaction conditions, high chemoselectivity, and adaptability to a variety of complex substrates [i.e., pyridinium salts derived from amines and partners derived from (hetero)aryl bromides]. ...[more]

PMID: 30993991

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