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Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.

ABSTRACT: Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism.

SUBMITTER: Lee C

PROVIDER: S-EPMC6512917 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.

Lee Changhan C

Molecular & cellular oncology 20190215 2

Cellular stress response is coordinated through the communication between mitochondria and the nucleus. However, whereas mitochondria are regulated by nuclear-encoded proteins, the nucleus was considered ungoverned by mitochondrial-encoded factors. We recently reported that a mitochondrial-encoded peptide directly regulates the nuclear genome upon cellular stress, indicating an integrated bi-genomic cross-communication mechanism. ...[more]

PMID: 31131297

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