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Targeting HER2 beyond breast cancer.

ABSTRACT: The structural basis of blocking human epidermal growth factor receptor-2 (HER2) dimerization remains of great interest to generate effective anti-cancer therapies. Despite clinically feasible outcome in mammary tumors, a fine consensus between efficacy and safety remains a critical challenge beyond breast cancer. Here we extrapolate on the balancing act using recently reported clinical findings in salivary ductal carcinomas.

SUBMITTER: Bhatnagar S

PROVIDER: S-EPMC6512921 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Targeting HER2 beyond breast cancer.

Bhatnagar Sanchita S Tushir-Singh Jogender J

Molecular & cellular oncology 20190320 3

The structural basis of blocking human epidermal growth factor receptor-2 (HER2) dimerization remains of great interest to generate effective anti-cancer therapies. Despite clinically feasible outcome in mammary tumors, a fine consensus between efficacy and safety remains a critical challenge beyond breast cancer. Here we extrapolate on the balancing act using recently reported clinical findings in salivary ductal carcinomas. ...[more]

PMID: 31131305

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