Ontology highlight
ABSTRACT:
SUBMITTER: Roux A
PROVIDER: S-EPMC6513100 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Roux Arthur A Leroy Héloise H De Muylder Bénédicte B Bracq Lucie L Oussous Samia S Dusanter-Fourt Isabelle I Chougui Ghina G Tacine Rachida R Randriamampita Clotilde C Desjardins Delphine D Le Grand Roger R Bouillaud Frederic F Benichou Serge S Margottin-Goguet Florence F Cheynier Remi R Bismuth Georges G Mangeney Marianne M
PLoS pathogens 20190501 5
HIV-1 is dependent on the host cell for providing the metabolic resources for completion of its viral replication cycle. Thus, HIV-1 replicates efficiently only in activated CD4+ T cells. Barriers preventing HIV-1 replication in resting CD4+ T cells include a block that limits reverse transcription and also the lack of activity of several inducible transcription factors, such as NF-κB and NFAT. Because FOXO1 is a master regulator of T cell functions, we studied the effect of its inhibition on T ...[more]