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VIRULIGN: fast codon-correct alignment and annotation of viral genomes.


ABSTRACT:

Summary

Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics of viral spread as well as to inform treatment and prevention strategies. However, the potential benefit of these applications critically depends on accurate and correctly annotated alignments of genetically heterogeneous data. VIRULIGN was built for fast codon-correct alignments of large datasets, with standardized and formalized genome annotation and various alignment export formats.

Availability and implementation

VIRULIGN is freely available at https://github.com/rega-cev/virulign as an open source software project.

Supplementary information

Supplementary data is available at Bioinformatics online.

SUBMITTER: Libin PJK 

PROVIDER: S-EPMC6513156 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

VIRULIGN: fast codon-correct alignment and annotation of viral genomes.

Libin Pieter J K PJK   Deforche Koen K   Abecasis Ana B AB   Theys Kristof K  

Bioinformatics (Oxford, England) 20190501 10


<h4>Summary</h4>Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics of viral spread as well as to inform treatment and prevention strategies. However, the potential benefit of these applications critically depends on accurate and correctly annotated alignments of genetically heterogeneous data. VIRULIGN was built for fast codon-correct alignments of large datasets, with standardized and formalized genome annotation and various alignment export formats.<h4>Ava  ...[more]

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