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ABSTRACT: Purpose
Swept-source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes.Design
A prospective, cross-sectional study.Methods
Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA). Both 3 × 3-mm and 6 × 6-mm scans were used to image the macular CC. Visualization of the CC and quantification of FDs were performed using a previously validated algorithm. The percentage of FDs (FD%) in the central 1-mm circle (C1), 1.5-mm rim (R1.5), and 2.5-mm circle (C2.5) from the 3 × 3-mm and 6 × 6-mm scans and FD% in the 2.5-mm rim (R2.5) and 5-mm circle (C5) from the 6 × 6-mm scans were measured and correlated with age and axial length.Results
A total of 164 subjects were enrolled, with at least 10 subjects from each decade of life. No meaningful correlations were found between FD% and axial length (|r| < 0.30). FD% in all fields increased with increasing age (all r > 0.50; all P < .001); however, the greatest increases were found in the central macula C1 regions and the smallest increases in the peripheral macula R2.5 regions.Conclusions
In normal aging, the FD% increased with age across the central 5 mm of the macula, but the greatest increase was found in the central 1-mm region of the macula.
SUBMITTER: Zheng F
PROVIDER: S-EPMC6513331 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zheng Fang F Zhang Qinqin Q Shi Yingying Y Russell Jonathan F JF Motulsky Elie H EH Banta James T JT Chu Zhongdi Z Zhou Hao H Patel Nimesh A NA de Sisternes Luis L Durbin Mary K MK Feuer William W Gregori Giovanni G Wang Ruikang R Rosenfeld Philip J PJ
American journal of ophthalmology 20190109
<h4>Purpose</h4>Swept-source optical coherence tomography angiography (SS-OCTA) was used to measure the age-dependent changes in macular choriocapillaris (CC) flow deficits (FDs) in normal eyes.<h4>Design</h4>A prospective, cross-sectional study.<h4>Methods</h4>Subjects with normal eyes ranging in age from their 20s to their 80s were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA). Both 3 × 3-mm and 6 × 6-mm scans were used to image the ma ...[more]