Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC6513754 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhang Zihui Z Russell Lloyd E LE Packer Adam M AM Gauld Oliver M OM Häusser Michael M
Nature methods 20181112 12
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity 'on the fly' du ...[more]