Bone morphogenetic proteins: Their role in regulating osteoclast differentiation.
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ABSTRACT:
SUBMITTER: Huntley R
PROVIDER: S-EPMC6513777 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Bone morphogenetic proteins: Their role in regulating osteoclast differentiation.
Huntley Raphael R Jensen Eric E Gopalakrishnan Rajaram R Mansky Kim C KC
Bone reports 20190505
The ability to create recombinant bone morphogenetic proteins (BMPs) in recent years has led to their rise as a common clinical adjuvant. Their application varies, from spinal fixation to repairing palatal clefts, to coating implants for osseointegration. In recent years questions have been raised as to the efficacy of BMPs in several of these procedures. These questions are due to the unwanted side effect of BMPs on other cell types, such as osteoclasts which can resorb bone at the graft/implan ...[more]
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