Ontology highlight
ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC6513986 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Luo Lei L Wang Yunfei Y Li Bowen B Xu Lizhen L Kamau Peter Muiruri PM Zheng Jie J Yang Fan F Yang Shilong S Lai Ren R
Nature communications 20190513 1
The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temper ...[more]