Ontology highlight
ABSTRACT:
SUBMITTER: Jain SU
PROVIDER: S-EPMC6513997 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190513 1
Posterior fossa type A (PFA) ependymomas exhibit very low H3K27 methylation and express high levels of EZHIP (Enhancer of Zeste Homologs Inhibitory Protein, also termed CXORF67). Here we find that a conserved sequence in EZHIP is necessary and sufficient to inhibit PRC2 catalytic activity in vitro and in vivo. EZHIP directly contacts the active site of the EZH2 subunit in a mechanism similar to the H3 K27M oncohistone. Furthermore, expression of H3 K27M or EZHIP in cells promotes similar chromat ...[more]