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Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration.

ABSTRACT: Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases.

SUBMITTER: Jantrapirom S

PROVIDER: S-EPMC6514573 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration.

Jantrapirom Salinee S Lo Piccolo Luca L Yamaguchi Masamitsu M

International journal of molecular sciences 20190417 8

Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In t ...[more]

PMID: 30999567

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