Ontology highlight
ABSTRACT:
SUBMITTER: Uchiyama T
PROVIDER: S-EPMC6515141 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Uchiyama Tomoko T Itaya-Hironaka Asako A Yamauchi Akiyo A Makino Mai M Sakuramoto-Tsuchida Sumiyo S Shobatake Ryogo R Ota Hiroyo H Takeda Maiko M Ohbayashi Chiho C Takasawa Shin S
International journal of molecular sciences 20190422 8
Sleep apnea syndrome (SAS), characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), is a risk factor for insulin resistance. Recently, IH is considered to independently cause adipose tissue inflammation/dysfunction, leading to worsening insulin resistance; however, the detailed mechanism remains unknown. We exposed mouse 3T3-L1 and human SW872 adipocytes to experimental IH or normoxia for 24 h, and analyzed mRNA expression of several adipokines. ...[more]