Circadian Analysis of the Mouse Cerebellum Proteome.
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ABSTRACT:
SUBMITTER: Plumel M
PROVIDER: S-EPMC6515515 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Circadian Analysis of the Mouse Cerebellum Proteome.
Plumel Marine M Dumont Stéphanie S Maes Pauline P Sandu Cristina C Felder-Schmittbuhl Marie-Paule MP Challet Etienne E Bertile Fabrice F
International journal of molecular sciences 20190415 8
The cerebellum contains a circadian clock, generating internal temporal signals. The daily oscillations of cerebellar proteins were investigated in mice using a large-scale two-dimensional difference in gel electrophoresis (2D-DIGE). Analysis of 2D-DIGE gels highlighted the rhythmic variation in the intensity of 27/588 protein spots (5%) over 24 h based on cosinor regression. Notably, the rhythmic expression of most abundant cerebellar proteins was clustered in two main phases (i.e., midday and ...[more]
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