Dataset Information

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy.

ABSTRACT:

Background

To investigate the one-year visual and anatomical outcomes of combination therapy with intravitreal aflibercept (IVA) and photodynamic therapy (PDT) for treating polypoidal choroidal vasculopathy (PCV).

Methods

This was a retrospective case-series study, including 30 eyes from 30 patients with treatment-naïve PCV treated by combination therapy with IVA and PDT. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complete polyp regression rate, and dry macula rate were recorded every 3?months during 12-month follow-up. Clinical factors associated with final visual outcome and retreatment were investigated.

Results

The mean LogMAR BCVA was significantly improved from 0.73?±?0.65 at baseline to 0.51?±?0.60 (p =?0.01), and the mean CRT was also significantly improved from 339?±?96??m at baseline to 244?±?43??m at 12-month follow-up (p ConclusionIn this study, combination therapy with IVA and PDT had significant visual and anatomical improvements to PCV patients during one-year follow-up. Better baseline BCVA and younger age were found to be associated with better visual outcome.

SUBMITTER: Weng HY

PROVIDER: S-EPMC6515633 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy.

Weng Hsin-Yu HY Huang Tzu-Lun TL Chang Pei-Yao PY Wang Jia-Kang JK

BMC pharmacology & toxicology 20190514 1

<h4>Background</h4>To investigate the one-year visual and anatomical outcomes of combination therapy with intravitreal aflibercept (IVA) and photodynamic therapy (PDT) for treating polypoidal choroidal vasculopathy (PCV).<h4>Methods</h4>This was a retrospective case-series study, including 30 eyes from 30 patients with treatment-naïve PCV treated by combination therapy with IVA and PDT. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complete polyp regression rate, and dry ...[more]

PMID: 31088543

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Project description:The optimal treatment for polypoidal choroidal vasculopathy (PCV) is still under debate. Little knowledge is known about the treatment effect of "1+pro re nata(PRN)" treatment regimen for PCV. The aim of this study was to compare the outcomes of photodynamic therapy (PDT), intravitreal ranibizumab injection (IVR) and combination therapy under the "1?+?PRN" treatment regimen for PCV.Fifty-seven eyes of 57 patients completed the 12 months' follow-up in this prospective study. The patients in the PDT arm(n?=?23), ranibizumab arm(n?=?18), or combination arm(n?=?16) underwent a session of PDT, IVR or combination of both at baseline followed by additional IVR as needed. Mean change of logarithm of the minimal angle of resolution (logMAR) visual acuity (VA), central foveal thickness (CFT) and the regression rate of polyps were evaluated. Cost-benefit analysis was also performed.At Month 12, the mean logMAR VA improved from 0.90?±?0.52 to 0.75?±?0.57 in the PDT group (P?<?0.05), from 0.96?±?0.58 to 0.77?±?0.41 in the IVR group (P?<?0.05), and from 0.94?±?0.55 to 0.72?±?0.44 in the combination group (P?<?0.05), respectively. The CFT decreased from 478.04?±?156.70 ?m, 527.5?±?195.90 ?m, and 522.63?±?288.40 ?m at the baseline to 366.43?±?148.28 ?m, 373.17?±?134.88 ?m and 328.44?±?103.25 in the PDT group (P?<?0.05), IVR group (P?<?0.01), and the combination group (P?<?0.05), respectively. However, no statistical difference was found between groups (P?>?0.05). PDT treatment (60.87%) was superior to the IVR therapy (22.22%) in achieving complete regression of polyps (P?<?0.05). Cost-benefit analysis showed that IVR treatment cost the least money for improving per 0.1logMAR units and the combination therapy demanded the least money for reducing per 100 ?m of CFT.PDT, IVR and the combination therapy have similar efficacy in the VA improvement as well as the reduction of CFT under the "1?+?PRN" treatment regimen.Current Controlled Trials NCT03459144 . Registered retrospectively on March 2, 2018.

Dataset Information

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy.

Background

Methods

Results

Publications

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy.

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