Dataset Information

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

ABSTRACT:

Aim

To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (INO) improves with fampridine treatment in patients with multiple sclerosis (MS).

Methods

Randomized, double-blind, placebo-controlled, cross-over trial with fampridine in patients with MS and INO. Horizontal saccades were recorded at baseline and at multiple time points post-dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (PV-VDI) and first-pass amplitude VDI (FPA-VDI). Both parameters were compared between fampridine and placebo using a mixed model analysis of variance taking patients as their own control. Pharmacokinetics was determined by serial blood sampling.

Results

Thirteen patients had a bilateral and 10 had a unilateral INO. One patient had an INO of abduction (posterior INO of Lutz) and was excluded. Fampridine significantly reduced both PV-VDI (-17.4%, 95% CI: -22.4%, -12.1%; P < 0.0001) and FPA-VDI (-12.5%, 95% CI: -18.9%, -5.5%; P < 0.01). Pharmacokinetics demonstrated that testing coincided with the average t_max at 2.08 hours (SD 45 minutes). The main adverse event reported after administration of fampridine was dizziness (61%).

Conclusion

Fampridine improves saccadic eye movements due to INO in MS. Treatment response to fampridine may gauge patient selection for inclusion to remyelination strategies in MS using saccadic eye movements as primary outcome measure.

SUBMITTER: Kanhai KMS

PROVIDER: S-EPMC6515699 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

Kanhai Kawita M S KMS Nij Bijvank Jenny A JA Wagenaar Yorick L YL Klaassen Erica S ES Lim KyoungSoo K Bergheanu Sandrin C SC Petzold Axel A Verma Ajay A Hesterman Jacob J Wattjes Mike P MP Uitdehaag Bernard M J BMJ van Rijn Laurentius J LJ Groeneveld Geert Jan GJ

CNS neuroscience & therapeutics 20190212 6

<h4>Aim</h4>To examine whether the velocity of saccadic eye movements in internuclear ophthalmoparesis (INO) improves with fampridine treatment in patients with multiple sclerosis (MS).<h4>Methods</h4>Randomized, double-blind, placebo-controlled, cross-over trial with fampridine in patients with MS and INO. Horizontal saccades were recorded at baseline and at multiple time points post-dose. Main outcome measures were the change of peak velocity versional dysconjugacy index (PV-VDI) and first-pas ...[more]

PMID: 30756475

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Dataset Information

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

Aim

Methods

Results

Conclusion

Publications

Treatment of internuclear ophthalmoparesis in multiple sclerosis with fampridine: A randomized double-blind, placebo-controlled cross-over trial.

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