Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures.
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ABSTRACT:
SUBMITTER: Tavares RCA
PROVIDER: S-EPMC6515926 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures.
Tavares Rafael C A RCA Pyle Anna Marie AM Somarowthu Srinivas S
Journal of molecular biology 20190316 8
The existence of evolutionary conservation in base pairing is strong evidence for functional elements of RNA structure, although available tools for rigorous identification of structural conservation are limited. R-scape is a recently developed program for statistical prediction of pairwise covariation from sequence alignments, but it initially showed limited utility on long RNAs, especially those of eukaryotic origin. Here we show that R-scape can be adapted for a more powerful analysis of stru ...[more]
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