Ontology highlight
ABSTRACT:
SUBMITTER: Romero A
PROVIDER: S-EPMC6516147 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Romero Alejandra A San Hipólito-Luengo Álvaro Á Villalobos Laura A LA Vallejo Susana S Valencia Inés I Michalska Patrycja P Pajuelo-Lozano Natalia N Sánchez-Pérez Isabel I León Rafael R Bartha José Luis JL Sanz María Jesús MJ Erusalimsky Jorge D JD Sánchez-Ferrer Carlos F CF Romacho Tania T Peiró Concepción C
Aging cell 20190217 3
Endothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human endothelial cell senescence and to identify intracellular pathways mediating its potential protective action. In human umbilical vein endothelial cell (HUVEC) cultures, Ang II promoted cell senescence, as revealed by the enhancement in senescence-associated galactosidase (S ...[more]