Ontology highlight
ABSTRACT:
SUBMITTER: Palmer AK
PROVIDER: S-EPMC6516193 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Palmer Allyson K AK Xu Ming M Zhu Yi Y Pirtskhalava Tamar T Weivoda Megan M MM Hachfeld Christine M CM Prata Larissa G LG van Dijk Theo H TH Verkade Esther E Casaclang-Verzosa Grace G Johnson Kurt O KO Cubro Hajrunisa H Doornebal Ewald J EJ Ogrodnik Mikolaj M Jurk Diana D Jensen Michael D MD Chini Eduardo N EN Miller Jordan D JD Matveyenko Aleksey A Stout Michael B MB Schafer Marissa J MJ White Thomas A TA Hickson LaTonya J LJ Demaria Marco M Garovic Vesna V Grande Joseph J Arriaga Edgar A EA Kuipers Folkert F von Zglinicki Thomas T LeBrasseur Nathan K NK Campisi Judith J Tchkonia Tamar T Kirkland James L JL
Aging cell 20190325 3
Adipose tissue inflammation and dysfunction are associated with obesity-related insulin resistance and diabetes, but mechanisms underlying this relationship are unclear. Although senescent cells accumulate in adipose tissue of obese humans and rodents, a direct pathogenic role for these cells in the development of diabetes remains to be demonstrated. Here, we show that reducing senescent cell burden in obese mice, either by activating drug-inducible "suicide" genes driven by the p16<sup>Ink4a</s ...[more]